Pineapple Bromelain Dren 200 Ml Farmaderbe

Description
Concentrated food supplement based on bromelain extracted from pineapple with high enzymatic activity and enriched with SOD to counteract the damage of oxidative stress. It promotes the drainage of body fluids, supports the functionality of the microcirculation and reduces the blemishes of cellulite, improving the tone and firmness of the skin. In addition, it has an important anti-inflammatory action and, taken after meals, it promotes digestion even in the case of large meals.

Property
-Pineapple: 90% water, but also contains: sugars, essential oil, organic acids (especially oxalic, citric and malic), vitamins A, B and C, amino acids, fibre and minerals (especially iron, calcium, manganese and potassium). Bromelain is concentrated in the fruit, but to a greater extent in the stem that supports it, an enzymatic mix of protease, phosphatase, peroxidase, amylase and cellulase that is the basis of all the biological activities recognized in the extract. Bromelain is active in a very wide pH range, between 4.5 and 9.5, is rapidly absorbed at intestinal level and has a half-life of about 6-9 hours. In it, the proteolytic activity is predominant and justifies the use of the extract to support digestion, after a meal. Thanks to characteristics similar to those of pepsin, it is in fact able to accelerate the digestion of proteins, preventing the formation of intestinal gas and the sensation of abdominal heaviness.
A further benefit conferred to the well-being of the legs derives from the antiplatelet activity of bromelain, the administration of which also involves a lower activation of platelet activation itself. As a fibrinolytic, it inhibits the formation of thrombi and can be successfully used in acute thrombophlebitis. It can also contribute to the reabsorption of hematomas. Due to the high concentration of antioxidant molecules, pineapple extract can also contribute to cardiovascular well-being, preventing the formation of atherosclerotic plaques in subjects with high hypercholesterolemia. Finally, the pineapple stem has an anti-inflammatory action whose mechanism is not well known, probably dependent on a proteolytic modulation of the molecular cascade underlying the inflammatory process. In addition to helping treat inflammatory conditions associated with trauma and edema, thanks to its effect on the immune response it is also proving promising in the management of chronic disorders such as asthma, sinusitis and rheumatoid arthritis, where it reduces inflammation and the infiltration of eosinophils and leukocytes. It is also used in pain control: in fact, it reduces acute knee pain in a dose-dependent manner in cases of osteoarthritis, and post-operative pain and edema.
-Superoxide dismutase: is a very important antioxidant present in almost all cells exposed to oxygen. It is the key enzyme that inactivates superoxide, the most reactive radical species that can damage membrane lipids, proteins and DNA. SOD has been used for years in general medicine for the management of anti-inflammatory diseases such as osteoarthritis, sports injuries and knee joint arthrosis. It is also used to protect against cardiovascular risk, to protect DNA from damage caused by oxidative stress and to counteract excess free radicals due to sports activity. It also improves cognitive abilities, is useful in controlling stress and can have immunoprotective actions.
-SuperOx-D: is a patented extract obtained from the Carrot which acts by inactivating the peroxide radical and also other radical forms which are generated upstream and downstream through quenching mechanisms.
-Centella: is a plant of Ayurvedic origin that combats cellulite blemishes and supports the well-being of the microcirculation. In particular, it stimulates the activity of fibroblasts and the synthesis of proline and alanine, essential amino acids for the formation of collagen. It normalizes the perivascular connective tissue with improved tone and elasticity of the venous wall. Furthermore, it stimulates the cells and tissues that participate in the healing process.

Ingredients
Demineralized water, maltodextrin, inulin, bromelain from pineapple (Ananas comosus (L.) Merr.) stem 2,500 GDU/g, flavourings; acidifiers: citric acid, malic acid; Superox-D superoxide dismutase 11,000 U/g from carrot (Daucus carota L.) root dry extract; preservatives: potassium sorbate, sodium benzoate; thickener: xanthan gum; centella [Centella asiatica (L.) Urb.] leaves dry extract 2% triterpenes, pineapple [Ananas comosus (L.) Merr.] stem dry extract 0.1% bromelain; sweetener: steviol glycosides.

Gluten free.

Nutritional characteristics

Average values ​​per 10 ml
Energy	49.95 kJ 11.86 kcal
Fats of which saturated of which monounsaturated of which polyunsaturated	<0.01g <0.005g <0.005g <0.005g
Carbohydrates of which sugars	2.43 g 0.26g
Fibers	<0.05g
Proteins	<0.01g
Salt	9.15 mg
Bromelain	500 mg
Superoxide dismutase	20 mg
Gotu kola is	10 mg
Pineapple is	10 mg

How to use
It is recommended to take 10 ml per day, diluted in 250 ml of water and consumed preferably in the morning to support drainage or in small sips during meals to aid digestion.

Warnings
Do not use during pregnancy, breastfeeding, pre-operative period, peptic ulcer, hepatitis; it may increase the absorption and half-life of antiplatelet agents, tetracyclines, hypoglycemics.

Conservation
Store at room temperature.
Validity with intact packaging: 36 months.

Format
200 ml bottle.

Code 180925

Bibliography
Barun KB "Bromelain: an overview". Nat. Prod. Rad. 7(4):359-363. 2008.
Maurer HR "Bromelain: biochemistry, pharmacology and medical use". Cell Mol. Life Sci. 58(9):1234-45. 2001.
Nguyen NH. et. al. "Anti-oxidative effects of superoxide dismutase 3 on inflammatory diseases". J. Mol. Med. (Berl). doi: 10.1007/s00109-019-01845-2. 2019.
Ordesi P. et al. "Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study". Quintessence Int. 45(8):679-84. 2014.
Rathnavelu V et al. "Potential role of bromelain in clinical and therapeutic applications". Biomed Rep. 5(3):283-288. 2016.
Vouldoukis I. et al. "Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract rich in superoxide dismutase activity". J. Ethnopharmacol. 94(1):67-75. 2004.