VITAMIN D3+K2 DROPS 30 ML ALGILIFE

Description
Food supplement based on vitamins D3, K2 of vegetal origin in sunflower seed oil. With essential oils of lemon and orange. The product is indicated to promote bone mineralization by promoting the absorption/use of calcium and phosphorus. It is therefore effective in improving osteoporosis associated with post-menopause by improving bone density and reducing the risk of fractures. It also has beneficial effects on muscle contraction and trophism as well as stimulating the immune system.

Ingredients
Sunflower seed oil, vitamin D (cholecalciferol) extracted from lichen [Cladonia rangiferina (L.) Weber ex FH Wigg.], vitamin K2 (menaquinone-7); antioxidant: alpha-tocopherol; orange (Citrus aurantium var. dulcis Hayne) essential oil, lemon [Citrus limon (L.) Osbeck.] essential oil.

Nutritional characteristics

Average values	For 12 drops equal to 0.5 ml
Vitamin D3 from lichen	50 mcg (1.000% NRV*)
Vitamin K2 (menaquinone-7)	25 mcg (33% NRV*)
Lemon or	0.2 mg
Orange or	0.2 mg

*NRV: Nutrient Reference Values.

How to use
-Adults: it is recommended to take a maximum of 12 drops per day.
-Adolescents and pregnant women: it is recommended to take a maximum of 6 drops per day.
-Children aged 3 years and over: it is recommended to take a maximum of 3 drops per day.

Warnings
Do not exceed the recommended daily dose. Keep out of reach of children under 3 years of age. Food supplements should not be considered as a substitute for a varied and balanced diet and lifestyle. Interactions or side effects: Vitamin K is known to interact with anticoagulant drugs.

Conservation
Store tightly closed in a cool, dry place, away from light. The expiry date refers to the product stored correctly, in an intact package.

Format
Capacity: 30 ml.

Bibliography
1. AA.VV. - PDR Nutritional Supplements, CEC Editore, Milan, 2003.
2. Vanherwegen AS, Gysemans C, Mathieu C. (2017) Regulation of Immune Function by Vitamin D and Its Use in Diseases of Immunity. Endocrinol Metab Clin North Am.
3. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. (2010) Vitamin D: modulator of the immune system. Curr Opin Pharmacol.
4. Aranow, Cynthia. (2011) “Vitamin D and the immune system.” Journal of investigative medicine: the official publication of the American Federation for Clinical Research vol. 59.6: 881-6. doi: 10.2310/JIM.0b013e31821b8755
5. Simes DC, Viegas CSB, Araújo N, Marreiros C. (2019) Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. Int J Mol Sci.A. Spiro and JL Buttriss, (2014) "Vitamin D: an overview of vitamin D status and intake in Europe," Nutrition Bulletin, vol. 39, pp. 322-350.
6. JC Fleet, (2017) "The role of vitamin D in the endocrinology controlling calcium homeostasis," Molecular and Cellular Endocrinology, vol. 17, pp. 30221-30226.
7. Adriana J. van Ballegooijen et al (2007) The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review International Journal of Endocrinology.
8. Beulens J et al (2013) The role of menaquinones (vitamin K2) in human health. Br J Nutr 110(8):1357–1368.
9. Maresz K (2015) Proper calcium use: Vitamin K2 as a promoter of bone and cardiovascular health. Integr Health 14(1):34-39.
10.Ikeda Y et al (2006) Intake of Fermented Soybeans, Natto, Is Associated with Reduced Bone Loss in Postmenopausal Women: Japanese Population-Based Osteoporosis (JPOS) Study.J Nutr 136(5):1323-1328.
11. Inaba N et al (2015) Low-Dose Daily Intake of Vitamin K2 (Menaquinone-7) Improves Osteocalcin?- Carboxylation: A Double-Blind, Randomized Controlled Trial. J Nutr Sci Vitaminol (Tokyo) 61(6):471-480.
12. Knapen M et al (2013) Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis Int 24(9):2499–2507.
13.Geleijnse J et al (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam study.